Source:http://linkedlifedata.com/resource/pubmed/id/18098291
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2008-2-25
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| pubmed:abstractText |
In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR = 0.67; (95% confidence interval (CI): 0.53-0.83; p-trend < 0.001). We hypothesized that variation in key folate metabolism genes may modify this association. Common variation in 5 folate metabolism genes (CBS: Ex9+33C > T (rs234706), Ex13 +41C > T (rs1801181), Ex18 -391 G > A (rs12613); MTHFR: A222V Ex5+79C > T (rs1801133), Ex8-62A > C (rs1801131); MTR: Ex26 20A > G (rs1805087), MTRR: Ex5+136 T > C (rs161870), and TYMS:IVS2-405 C > T (rs502396), Ex8+157 C > T (rs699517), Ex8+227 A > G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR = 1.44; 95% CI: 1.17-1.77; p = 0.001). After stratification by tertile of vegetable intake, the higher risk associated with the variant genotype was only observed in the low and medium tertiles (p-trend = 0.001), but not among those in the highest tertile (p-interaction = 0.22). The association remained robust after calculation of the false discovery rate (FDR = 0.05). Of the 3 TYMS SNPs examined, only the TYMS IVS2 -405 C (rs502396) variant was associated with a significantly lower risk compared to the common genotype (OR = 0.73; 95% CI: 0.57-0.93). Vegetable intake modified the association between all 3 TYMS SNPs and RCC risk (p-interaction < 0.04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1097-0215
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| pubmed:author |
pubmed-author:BenckoVladmirV,
pubmed-author:BerndtSonyaS,
pubmed-author:BoffettaPaoloP,
pubmed-author:BrennanPaulP,
pubmed-author:ChanockStephenS,
pubmed-author:ChowWong-HoWH,
pubmed-author:Garcia-ClosasMontseM,
pubmed-author:HolcatovaIvanaI,
pubmed-author:HsuCharles CCC,
pubmed-author:HungRayjeanR,
pubmed-author:JanoutVladimirV,
pubmed-author:KaramiSaraS,
pubmed-author:KollarovaHelenH,
pubmed-author:MatesDanaD,
pubmed-author:MooreLee ELE,
pubmed-author:MukeriaAnushA,
pubmed-author:NavratilovaMarieM,
pubmed-author:RothmanNatN,
pubmed-author:Szeszenia-DabrowskaNN,
pubmed-author:YeagerMeredithM,
pubmed-author:ZaridzeDavidD
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
122
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1710-5
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| pubmed:meshHeading |
pubmed-meshheading:18098291-Adult,
pubmed-meshheading:18098291-Aged,
pubmed-meshheading:18098291-Carcinoma, Renal Cell,
pubmed-meshheading:18098291-Case-Control Studies,
pubmed-meshheading:18098291-Europe, Eastern,
pubmed-meshheading:18098291-Female,
pubmed-meshheading:18098291-Folic Acid,
pubmed-meshheading:18098291-Food Habits,
pubmed-meshheading:18098291-Haplotypes,
pubmed-meshheading:18098291-Humans,
pubmed-meshheading:18098291-Kidney Neoplasms,
pubmed-meshheading:18098291-Male,
pubmed-meshheading:18098291-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:18098291-Middle Aged,
pubmed-meshheading:18098291-Odds Ratio,
pubmed-meshheading:18098291-Polymorphism, Genetic,
pubmed-meshheading:18098291-Risk Assessment,
pubmed-meshheading:18098291-Risk Factors,
pubmed-meshheading:18098291-Signal Transduction,
pubmed-meshheading:18098291-Thymidylate Synthase,
pubmed-meshheading:18098291-Vegetables
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| pubmed:year |
2008
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| pubmed:articleTitle |
Folate metabolism genes, vegetable intake and renal cancer risk in central Europe.
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| pubmed:affiliation |
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA. moorele@mail.nih.gov
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|