Source:http://linkedlifedata.com/resource/pubmed/id/18097733
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-1-31
|
| pubmed:abstractText |
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1434-5161
|
| pubmed:author |
pubmed-author:FurutaHirotoH,
pubmed-author:HaraKazuoK,
pubmed-author:HinokioYoshinoriY,
pubmed-author:HirotaYushiY,
pubmed-author:HorikawaYukioY,
pubmed-author:IwamotoYasuhikoY,
pubmed-author:IwasakiNaokoN,
pubmed-author:KadowakiTakashiT,
pubmed-author:KashiwagiAtsunoriA,
pubmed-author:KasugaMasatoM,
pubmed-author:MaegawaHiroshiH,
pubmed-author:MakinoHideichiH,
pubmed-author:MiyakeKazuakiK,
pubmed-author:NanjoKishioK,
pubmed-author:OkaYoshitomoY,
pubmed-author:OsawaHaruhikoH,
pubmed-author:SeinoYutakaY,
pubmed-author:TakedaJunJ,
pubmed-author:TokunagaKatsushiK,
pubmed-author:YamadaYuichiroY,
pubmed-author:YamagataKazuyaK,
pubmed-author:YamamotoKenK,
pubmed-author:YasudaKazukiK
|
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
174-80
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:18097733-Aged,
pubmed-meshheading:18097733-Alleles,
pubmed-meshheading:18097733-Case-Control Studies,
pubmed-meshheading:18097733-Diabetes Mellitus, Type 2,
pubmed-meshheading:18097733-Female,
pubmed-meshheading:18097733-Genetic Predisposition to Disease,
pubmed-meshheading:18097733-Genotype,
pubmed-meshheading:18097733-Haplotypes,
pubmed-meshheading:18097733-Humans,
pubmed-meshheading:18097733-Japan,
pubmed-meshheading:18097733-Male,
pubmed-meshheading:18097733-Middle Aged,
pubmed-meshheading:18097733-Polymorphism, Single Nucleotide,
pubmed-meshheading:18097733-Risk Factors,
pubmed-meshheading:18097733-TCF Transcription Factors,
pubmed-meshheading:18097733-Transcription Factor 7-Like 2 Protein
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
|
| pubmed:affiliation |
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|