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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-2-15
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pubmed:abstractText |
High blockade of dopamine D2 receptors in the ventral striatum including the nucleus accumbens may interfere with reward anticipation and cause secondary negative symptoms such as apathy or anhedonia. This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
673-84
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18097655-Adult,
pubmed-meshheading:18097655-Analysis of Variance,
pubmed-meshheading:18097655-Antipsychotic Agents,
pubmed-meshheading:18097655-Benzodiazepines,
pubmed-meshheading:18097655-Female,
pubmed-meshheading:18097655-Flupenthixol,
pubmed-meshheading:18097655-Fluphenazine,
pubmed-meshheading:18097655-Haloperidol,
pubmed-meshheading:18097655-Humans,
pubmed-meshheading:18097655-Magnetic Resonance Imaging,
pubmed-meshheading:18097655-Male,
pubmed-meshheading:18097655-Motivation,
pubmed-meshheading:18097655-Neostriatum,
pubmed-meshheading:18097655-Nucleus Accumbens,
pubmed-meshheading:18097655-Oxygen,
pubmed-meshheading:18097655-Psychomotor Performance,
pubmed-meshheading:18097655-Reaction Time,
pubmed-meshheading:18097655-Receptors, Dopamine D2,
pubmed-meshheading:18097655-Reward,
pubmed-meshheading:18097655-Schizophrenia,
pubmed-meshheading:18097655-Schizophrenic Psychology
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pubmed:year |
2008
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pubmed:articleTitle |
Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine.
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pubmed:affiliation |
Department of Psychiatry and Psychotherapy, Charité University Medical Center, Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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