Source:http://linkedlifedata.com/resource/pubmed/id/18097575
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2007-12-21
|
| pubmed:abstractText |
To elucidate the prognostic role and relationship of the p53/p21/PCNA pathway in gastrointestinal stromal tumors (GISTs), a total of 167 resected gastric and small intestinal CD117-positive stromal tumor specimens were collected from January 1987 to December 2000. Immunohistochemical studies were performed on the paraffin sections with antibodies of p53, p21/WAF1, proliferating cell nuclear antigen (PCNA) and Ki-67. The immunoreactivity of four markers was recorded by labeling index (LI, %) for clinicopathologic and survival correlation. The labeling index was 0-83% for p53, 0-81% for p21/WAF1, 0-33% for Ki-67 and 12-92% for PCNA. Completely negative immunostaining (LI<1%) was found in 54.5% of p53, 25.8% of p21/WAF1 and 44.3% of Ki-67. The LI of four markers strongly correlate with each other (p<0.05). Furthermore, the LI of all four markers positively correlate to microscopic tumor mitotic counts (p<0.05). Only the LI of p53 and PCNA positively correlate to tumor sizes. Tumors with non-spindle cell type (versus spindle cell) and high cellular pleomorphism (versus low) exhibited a higher p53, p21/WAF1 and PCNA LI (p<0.05). Increased NIH risk significantly correlates to increased p53, PCNA and Ki-67 (p<0.05) LI. Survival analysis indicated that a large tumor size (> or =5 cm, p=0.003), increased tumor mitosis (> or =5/50 HPF, p<0.001), high NIH risk (p<0.001), non-spindle cell type (p=0.024), high p53 LI (p<0.001), high p21/WAF1 LI (p=0.007), high Ki-67 LI (p<0.001) and high PCNA LI (p<0.001) were prognostic factors for poor disease-free survival. Independent factors are tumor size, NIH risk, p53 and p21/WAF1 LI. We demonstrated the first evidence of the linear relationship and prognostic role of the p53/p21/PCNA pathway in gastrointestinal stromal tumors. Abnormalities of the p53/p21WAF1 pathway lead to increased proliferating states, thereby triggering the progression of GISTs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1021-335X
|
| pubmed:author |
pubmed-author:ChangchienChi-SinCS,
pubmed-author:ChiuYi-ChunYC,
pubmed-author:ChouYeh-PinYP,
pubmed-author:ChuahSeng-KeeSK,
pubmed-author:HuTsung-HuiTH,
pubmed-author:HuangChao-ChengCC,
pubmed-author:LeachT JTJ,
pubmed-author:LeeChuan-MoCM,
pubmed-author:LinJui-WeiJW,
pubmed-author:TaiMing-HongMH,
pubmed-author:WangChih-ChiCC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
49-56
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:18097575-Adult,
pubmed-meshheading:18097575-Aged,
pubmed-meshheading:18097575-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:18097575-Disease Progression,
pubmed-meshheading:18097575-Disease-Free Survival,
pubmed-meshheading:18097575-Female,
pubmed-meshheading:18097575-Gastrointestinal Stromal Tumors,
pubmed-meshheading:18097575-Humans,
pubmed-meshheading:18097575-Immunohistochemistry,
pubmed-meshheading:18097575-Infant, Newborn,
pubmed-meshheading:18097575-Kaplan-Meier Estimate,
pubmed-meshheading:18097575-Ki-67 Antigen,
pubmed-meshheading:18097575-Male,
pubmed-meshheading:18097575-Middle Aged,
pubmed-meshheading:18097575-Prognosis,
pubmed-meshheading:18097575-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:18097575-Tumor Markers, Biological,
pubmed-meshheading:18097575-Tumor Suppressor Protein p53
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
The abnormalities in the p53/p21WAF1 pathway have a significant role in the pathogenesis and progression of gastrointestinal stromal tumors.
|
| pubmed:affiliation |
Division of Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao-Sung Hsiang, Kaohsiung Hsien 833, Kaohsiung, Taiwan.
|
| pubmed:publicationType |
Journal Article
|