Linked Life Data

18097163

Source:http://linkedlifedata.com/resource/pubmed/id/18097163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-21
pubmed:abstractText
Motor neuron disease (MND) is a neurodegenerative condition long thought to be associated only with motor weakness. Recent work now shows that cognitive difficulties are present in up to half of the patients with this disorder. About 5-10% of patients with MND have a frank dementia that resembles frontotemporal lobar degeneration (FTLD). Imaging studies show quantitative abnormalities that resemble FTLD. Moreover, biochemical studies of ubiquinated histopathologic abnormalities in MND and FTLD reveal identical inclusions of TDP-43. These findings underline a fundamental link between MND and FTLD. This paper reviews this body of work.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1424-862X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-90
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Motor neuron disease and frontotemporal lobar degeneration: a tale of two disorders linked to TDP-43.
pubmed:affiliation
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. elmanl@uphs.upenn.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural