Source:http://linkedlifedata.com/resource/pubmed/id/18097037
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-12-21
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pubmed:abstractText |
CD20 mAb-mediated B cell depletion is an effective treatment for B cell malignancies and some autoimmune diseases. However, the full effects of B cell depletion on natural, primary, and secondary Ab responses and the maintenance of Ag-specific serum Ig levels are largely unknown. The relationship between memory B cells, long-lived plasma cells, and long-lived humoral immunity also remains controversial. To address the roles of B cell subsets in the longevity of humoral responses, mature B cells were depleted in mice using CD20 mAb. Peritoneal B cell depletion reduced natural and Ag-induced IgM responses. Otherwise, CD20+ B cell depletion prevented humoral immune responses and class switching and depleted existing and adoptively transferred B cell memory. Nonetheless, B cell depletion did not affect serum Ig levels, Ag-specific Ab titers, or bone marrow Ab-secreting plasma cell numbers. Coblockade of LFA-1 and VLA-4 adhesion molecules temporarily depleted long-lived plasma cells from the bone marrow. CD20+ B cell depletion plus LFA-1/VLA-4 mAb treatment significantly prolonged Ag-specific plasma cell depletion from the bone marrow, with a significant decrease in Ag-specific serum IgG. Collectively, these results support previous claims that bone marrow plasma cells are intrinsically long-lived. Furthermore, these studies now demonstrate that mature and memory B cells are not required for maintaining bone marrow plasma cell numbers, but are required for repopulation of plasma cell-deficient bone marrow. Thereby, depleting mature and memory B cells does not have a dramatic negative effect on preexisting Ab levels.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI24335,
http://linkedlifedata.com/resource/pubmed/grant/AI56363,
http://linkedlifedata.com/resource/pubmed/grant/AI67584,
http://linkedlifedata.com/resource/pubmed/grant/CA105001,
http://linkedlifedata.com/resource/pubmed/grant/CA81776,
http://linkedlifedata.com/resource/pubmed/grant/CA96547
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-71
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pubmed:meshHeading |
pubmed-meshheading:18097037-Animals,
pubmed-meshheading:18097037-Antibodies,
pubmed-meshheading:18097037-Antibodies, Monoclonal,
pubmed-meshheading:18097037-Antigens, CD20,
pubmed-meshheading:18097037-Autoimmune Diseases,
pubmed-meshheading:18097037-B-Lymphocyte Subsets,
pubmed-meshheading:18097037-Bone Marrow Cells,
pubmed-meshheading:18097037-Immunoglobulin G,
pubmed-meshheading:18097037-Immunologic Memory,
pubmed-meshheading:18097037-Immunotherapy,
pubmed-meshheading:18097037-Integrin alpha4beta1,
pubmed-meshheading:18097037-Lymphocyte Depletion,
pubmed-meshheading:18097037-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:18097037-Lymphoma, B-Cell,
pubmed-meshheading:18097037-Mice,
pubmed-meshheading:18097037-Mice, Inbred Strains,
pubmed-meshheading:18097037-Plasma Cells
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pubmed:year |
2008
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pubmed:articleTitle |
Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.
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pubmed:affiliation |
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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