Linked Life Data

18095855

Source:http://linkedlifedata.com/resource/pubmed/id/18095855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-12-21
pubmed:abstractText
Despite being known for decades (since 1934), electrospinning has emerged recently as a very widespread technology to produce synthetic nanofibrous structures. These structures have morphologies and fiber diameters in a range comparable with those found in the extracellular matrix of human tissues. Therefore, nanofibrous scaffolds are intended to provide improved environments for cell attachment, migration, proliferation and differentiation when compared with traditional scaffolds. In addition, the process versatility and the highly specific surface area of nanofiber meshes may facilitate their use as local drug-release systems. Common electrospun nanofiber meshes are characterized by a random orientation. However, in some special cases, aligned distributions of the fibers can be obtained, with an interconnected microporous structure. The characteristic pore sizes and the inherent planar structure of the meshes can be detrimental for the desired cell infiltration into the inner regions, and eventually compromise tissue regeneration. Several strategies can be followed to overcome these limitations, and are discussed in detail here.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1748-6963
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
929-42
pubmed:dateRevised
2010-1-28
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Electrospun nanostructured scaffolds for tissue engineering applications.
pubmed:affiliation
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't