18094423

Source:http://linkedlifedata.com/resource/pubmed/id/18094423

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0027651, umls-concept:C0030705, umls-concept:C0034897, umls-concept:C0201734, umls-concept:C0555198, umls-concept:C1521970, umls-concept:C1704711, umls-concept:C1707080
pubmed:issue	24
pubmed:dateCreated	2007-12-20
pubmed:abstractText	To characterize the pharmacokinetics of temsirolimus and its major metabolite, sirolimus, in patients receiving enzyme-inducing antiepileptic drugs (EIAED) compared with patients receiving non-EIAEDs. An additional objective was to determine whether concentrations of temsirolimus or sirolimus were achieved in brain tumor tissue.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA16672, http://linkedlifedata.com/resource/pubmed/grant/CA62412, http://linkedlifedata.com/resource/pubmed/grant/CA62455, http://linkedlifedata.com/resource/pubmed/grant/M01-RR00042, http://linkedlifedata.com/resource/pubmed/grant/M01-RR00079, http://linkedlifedata.com/resource/pubmed/grant/M01-RR00633, http://linkedlifedata.com/resource/pubmed/grant/M01-RR03186, http://linkedlifedata.com/resource/pubmed/grant/M01-RR0865, http://linkedlifedata.com/resource/pubmed/grant/P30CA54174, http://linkedlifedata.com/resource/pubmed/grant/U01CA62339, http://linkedlifedata.com/resource/pubmed/grant/U01CA62399, http://linkedlifedata.com/resource/pubmed/grant/U01CA62407, http://linkedlifedata.com/resource/pubmed/grant/U01CA62421, http://linkedlifedata.com/resource/pubmed/grant/U01CA62422, http://linkedlifedata.com/resource/pubmed/grant/U01CA62426
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus, http://linkedlifedata.com/resource/pubmed/chemical/temsirolimus
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1078-0432
pubmed:author	pubmed-author:ChangSusan MSM, pubmed-author:CloughesyTimothy FTF, pubmed-author:ConradCharlesC, pubmed-author:DanceyJanetJ, pubmed-author:DeAngelisLisaL, pubmed-author:FinkKaren LKL, pubmed-author:GreenbergHarryH, pubmed-author:HessKennethK, pubmed-author:KuhnJohn GJG, pubmed-author:LambornKathleen RKR, pubmed-author:MehtaMineshM, pubmed-author:North American Brain Tumor Consortium and the National Cancer Institute, pubmed-author:PradosMichael DMD, pubmed-author:RaizerJeffreyJ, pubmed-author:RobinsH IanHI, pubmed-author:SchiffDavidD, pubmed-author:WenPatrick YPY
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7401-6
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:18094423-Anticonvulsants, pubmed-meshheading:18094423-Antineoplastic Agents, pubmed-meshheading:18094423-Area Under Curve, pubmed-meshheading:18094423-Brain Neoplasms, pubmed-meshheading:18094423-Cytochrome P-450 CYP3A, pubmed-meshheading:18094423-Cytochrome P-450 Enzyme System, pubmed-meshheading:18094423-Drug Interactions, pubmed-meshheading:18094423-Glioma, pubmed-meshheading:18094423-Humans, pubmed-meshheading:18094423-Maximum Tolerated Dose, pubmed-meshheading:18094423-Metabolic Clearance Rate, pubmed-meshheading:18094423-Neoplasm Recurrence, Local, pubmed-meshheading:18094423-Sirolimus
pubmed:year	2007
pubmed:articleTitle	Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma.
pubmed:affiliation	Pharmacotherapy Education and Research Center, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Kuhn@uthscsa.edu
pubmed:publicationType	Journal Article, Clinical Trial, Phase II, Clinical Trial, Phase I, Research Support, N.I.H., Extramural