|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2007-12-19
|
|
pubmed:abstractText |
Sphingosine-1-phosphate (S1P) has been considered to play an important role in ischemia/reperfusion (I/R) injury. We used SEW2871 (SEW), a novel receptor-selective agonist for S1P1, to elucidate the role of S1P1 in myocardial I/R. Isolated perfused rat hearts exposed to S1P (1 and 10 mM) or SEW (1 and 0.1 mM) were subjected to 30 minutes of global no-flow ischemia and 2 hours of reperfusion. S1P at 1 and 10 mM significantly reduced infarct size and CK release compared with vehicle-control. The effect of 0.1 microM SEW on infarct size was modest. After I/R, S1P at both doses and SEW at 0.1 microM improved developed pressure (LVDP). SEW at 1 mM significantly prolonged the duration of ventricular tachycardia and ventricular fibrillation, leading to irreversible reperfusion tachyarrhythmias in 60% of the hearts. This is the first demonstration of the critical role of the S1P1 receptor in I/R injury.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0160-2446
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
660-9
|
|
pubmed:meshHeading |
pubmed-meshheading:18091583-Aniline Compounds,
pubmed-meshheading:18091583-Animals,
pubmed-meshheading:18091583-Arrhythmias, Cardiac,
pubmed-meshheading:18091583-Dose-Response Relationship, Drug,
pubmed-meshheading:18091583-Heart,
pubmed-meshheading:18091583-Male,
pubmed-meshheading:18091583-Models, Biological,
pubmed-meshheading:18091583-Molecular Structure,
pubmed-meshheading:18091583-Myocardial Infarction,
pubmed-meshheading:18091583-Myocardial Reperfusion Injury,
pubmed-meshheading:18091583-Oxadiazoles,
pubmed-meshheading:18091583-Perfusion,
pubmed-meshheading:18091583-Phenyl Ethers,
pubmed-meshheading:18091583-Rats,
pubmed-meshheading:18091583-Rats, Sprague-Dawley,
pubmed-meshheading:18091583-Receptors, Lysosphingolipid,
pubmed-meshheading:18091583-Sodium-Calcium Exchanger,
pubmed-meshheading:18091583-Thiophenes,
pubmed-meshheading:18091583-Time Factors,
pubmed-meshheading:18091583-Ventricular Function, Left
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.
|
|
pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
|
