|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2007-12-19
|
|
pubmed:abstractText |
Nuclear factor-kappaB is a key transcriptional factor in the regulation of inflammatory factors that are involved in tissue reperfusion injury, but conflicting data have been presented in the literature. The proteasome regulates proteins that control cell-cycle progression and apoptosis, and inhibition of the proteasome has been shown to reduce nuclear factor-kappaB activation and reperfusion injury. Although bortezomib is a potent proteasome inhibitor, its role in skeletal muscle reperfusion injury has not been documented, and its effects on the regulation of inflammatory factors in reperfused tissue are unclear. In this study, the authors investigated the role of nuclear factor-kappaB in skeletal muscle reperfusion injury and the effect of bortezomib (a proteasome inhibitor) on reperfusion injury.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Boronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Icam1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IkappaBNS protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Nfkb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/bortezomib
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1529-4242
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1808-18
|
|
pubmed:dateRevised |
2011-2-16
|
|
pubmed:meshHeading |
pubmed-meshheading:18090742-Animals,
pubmed-meshheading:18090742-Blood Vessels,
pubmed-meshheading:18090742-Boronic Acids,
pubmed-meshheading:18090742-Drug Evaluation, Preclinical,
pubmed-meshheading:18090742-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18090742-Laser-Doppler Flowmetry,
pubmed-meshheading:18090742-Male,
pubmed-meshheading:18090742-Mice,
pubmed-meshheading:18090742-Microscopy, Video,
pubmed-meshheading:18090742-Muscle, Skeletal,
pubmed-meshheading:18090742-NF-kappa B p50 Subunit,
pubmed-meshheading:18090742-Nitric Oxide Synthase Type II,
pubmed-meshheading:18090742-Protease Inhibitors,
pubmed-meshheading:18090742-Proteasome Endopeptidase Complex,
pubmed-meshheading:18090742-Proteins,
pubmed-meshheading:18090742-Pyrazines,
pubmed-meshheading:18090742-Random Allocation,
pubmed-meshheading:18090742-Reperfusion Injury,
pubmed-meshheading:18090742-Surgical Flaps,
pubmed-meshheading:18090742-Tyrosine
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
|
|
pubmed:affiliation |
Department of Orthopedic Surgery, College of Medicine, Korea University, Seoul, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
