Source:http://linkedlifedata.com/resource/pubmed/id/18090506
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2007-12-19
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| pubmed:abstractText |
The investigation of compliance in patients with major depressive disorder (in drop-outs versus completers and in first episode versus recurrent episode patients). A total of 85 outpatients with major depressive disorder were followed for 6 months. Different dimensions of compliance were investigated: drop-outs versus completers and their medication adherence (with electronic monitoring). General linear mixed models were applied to examine the time courses of adherence. Drop-out rates were higher in younger patients and in patients with a lower initial depression severity. The adherence during 6 months of treatment with selective serotonin reuptake inhibitors was above 80 in 70% of the patients. The adherence decreased by 2.5% per month and decreased more than three times more rapidly in drop-outs (from baseline to time of drop-out). A medical visit resulted in a temporary increase in pill intake. General linear mixed model analysis showed that the predicted outcome was worse in drop-outs than in completers and worse in recurrent episode patients than in first episode patients (the former showing a higher adherence). Adherence decreases with time during 6 months of treatment with antidepressants and is influenced by demographic and clinical variables. Completers show a higher adherence than drop-outs. The outcome was worse in recurrent episode patients than first episode patients although they had a higher adherence.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0268-1315
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
36-42
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| pubmed:meshHeading |
pubmed-meshheading:18090506-Adult,
pubmed-meshheading:18090506-Antidepressive Agents,
pubmed-meshheading:18090506-Depressive Disorder, Major,
pubmed-meshheading:18090506-Disease Progression,
pubmed-meshheading:18090506-Female,
pubmed-meshheading:18090506-Humans,
pubmed-meshheading:18090506-Linear Models,
pubmed-meshheading:18090506-Longitudinal Studies,
pubmed-meshheading:18090506-Male,
pubmed-meshheading:18090506-Middle Aged,
pubmed-meshheading:18090506-Models, Statistical,
pubmed-meshheading:18090506-Patient Compliance,
pubmed-meshheading:18090506-Patient Dropouts,
pubmed-meshheading:18090506-Psychiatric Status Rating Scales,
pubmed-meshheading:18090506-Recurrence,
pubmed-meshheading:18090506-Socioeconomic Factors
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Six-month compliance with antidepressant medication in the treatment of major depressive disorder.
|
| pubmed:affiliation |
University Hospital Gasthuisberg, Belgium. koen.demyttenaere@med.kuleuven.be
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| pubmed:publicationType |
Journal Article
|