rdf:type |
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0024432,
umls-concept:C0079189,
umls-concept:C0205314,
umls-concept:C0439064,
umls-concept:C0679622,
umls-concept:C1416390,
umls-concept:C1424658,
umls-concept:C1426048,
umls-concept:C1515877,
umls-concept:C1752924,
umls-concept:C1879547
|
pubmed:issue |
1
|
pubmed:dateCreated |
2007-12-19
|
pubmed:abstractText |
IL-27 is a novel anti-HIV cytokine that inhibits HIV-1 replication in both CD4 T cells and monocyte-derived macrophages (MDM) as IFN-alpha does. To elucidate the mechanism of the antiviral activity, we compared the activity and the gene expression profile of IL-27-treated cells with that of IFN-alpha-treated cells.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1473-5571
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
2
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
39-45
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:18090390-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18090390-Cells, Cultured,
pubmed-meshheading:18090390-Culture Media, Conditioned,
pubmed-meshheading:18090390-Dose-Response Relationship, Drug,
pubmed-meshheading:18090390-Gene Expression Regulation, Viral,
pubmed-meshheading:18090390-Genes, Viral,
pubmed-meshheading:18090390-HIV Infections,
pubmed-meshheading:18090390-HIV-1,
pubmed-meshheading:18090390-Interferon-alpha,
pubmed-meshheading:18090390-Interleukins,
pubmed-meshheading:18090390-Macrophages,
pubmed-meshheading:18090390-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18090390-Virus Replication
|
pubmed:year |
2008
|
pubmed:articleTitle |
IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages.
|
pubmed:affiliation |
Laboratory of Human Retrovirology, National Cancer Institute at Frederick, Frederick, Maryland, USA. timamichi@mail.nih.gov
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|