Source:http://linkedlifedata.com/resource/pubmed/id/18089679
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2007-12-19
|
| pubmed:abstractText |
The objective of this study is to evaluate the association between anti-neuronal antibody (anti-NA) and central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) and other rheumatic diseases using a flow cytometric method. Anti-NA was measured by flow cytometry in serum and cerebrospinal fluid (CSF) samples from patients with SLE (n=44 for serum, n=17 for CSF), other rheumatic diseases (n=64 for serum, n=21 for CSF) and from healthy controls (n=65 for serum, n=18 for CSF). Serum anti-NA was more frequently observed in SLE (31.8%, 14/44) than in other rheumatic diseases (4.7%, 3/64, P<0.001) or in healthy controls (0%, 0/65, P<0.00001). In SLE patients, the frequency of serum anti-NA was significantly higher in CNS-SLE (76.5%, 13/17) than in non CNS-SLE (3.7%, 1/27, P<0.000001). CSF anti-NA was detected in 88.2% (15/17) of CNS-SLE and was more frequently detected in CNS-SLE (15/17, 88.2%) than in other rheumatic diseases with CNS involvement (1/21, 4.8%, P<0.000001) or in healthy controls (0/18, P<0.000001). In conclusion, serum anti-NA was more frequently found in CNS-SLE than in non CNS-SLE, other rheumatic diseases or in healthy controls. The frequency of CSF anti-NA in CNS-SLE was significantly higher than in other rheumatic diseases with CNS involvement or in healthy controls.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0961-2033
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
21-5
|
| pubmed:dateRevised |
2011-3-11
|
| pubmed:meshHeading |
pubmed-meshheading:18089679-Adult,
pubmed-meshheading:18089679-Autoantibodies,
pubmed-meshheading:18089679-Cell Line, Tumor,
pubmed-meshheading:18089679-Cerebrovascular Disorders,
pubmed-meshheading:18089679-Confusion,
pubmed-meshheading:18089679-Epilepsy,
pubmed-meshheading:18089679-Female,
pubmed-meshheading:18089679-Flow Cytometry,
pubmed-meshheading:18089679-Headache Disorders,
pubmed-meshheading:18089679-Humans,
pubmed-meshheading:18089679-Lupus Erythematosus, Systemic,
pubmed-meshheading:18089679-Lupus Vasculitis, Central Nervous System,
pubmed-meshheading:18089679-Male,
pubmed-meshheading:18089679-Meningitis, Aseptic,
pubmed-meshheading:18089679-Middle Aged,
pubmed-meshheading:18089679-Neurons,
pubmed-meshheading:18089679-Psychotic Disorders,
pubmed-meshheading:18089679-Rheumatic Diseases,
pubmed-meshheading:18089679-Up-Regulation
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases.
|
| pubmed:affiliation |
Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, College of Medicine, Seoul, Republic of Korea.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|