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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-12-18
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pubmed:abstractText |
Using time lapse intravital microscopy and histology, we previously reported that we could not detect migration of antigen-presenting cells from the iris to the regional lymph node. Dendritic cells (DC) in other peripheral tissues migrate to lymph nodes in response to chemokines, CCL19 (ELC) and CCL21b (SLC), that activate the CCR7 receptor. We hypothesized that DCs in an inflamed iris might show a different chemokine receptor and ligand profile, thus explaining the DC's inability to migrate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2209-13
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pubmed:meshHeading |
pubmed-meshheading:18087238-Animals,
pubmed-meshheading:18087238-Endotoxins,
pubmed-meshheading:18087238-Female,
pubmed-meshheading:18087238-Inflammation,
pubmed-meshheading:18087238-Iris,
pubmed-meshheading:18087238-Ligands,
pubmed-meshheading:18087238-Lymphatic Vessels,
pubmed-meshheading:18087238-Mice,
pubmed-meshheading:18087238-Mice, Inbred BALB C,
pubmed-meshheading:18087238-RNA, Messenger,
pubmed-meshheading:18087238-Receptors, CCR7,
pubmed-meshheading:18087238-Up-Regulation,
pubmed-meshheading:18087238-Uveitis
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pubmed:year |
2007
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pubmed:articleTitle |
Endotoxin upregulates CCR7 and its ligands in the lymphatic-free mouse iris.
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pubmed:affiliation |
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA. Friederike.Mackensen@uveitiszentrum.de
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pubmed:publicationType |
Journal Article
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