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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-26
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pubmed:abstractText |
Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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|
pubmed:issn |
0066-4804
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18086835-Animals,
pubmed-meshheading:18086835-Aspergillosis,
pubmed-meshheading:18086835-Aspergillus fumigatus,
pubmed-meshheading:18086835-Immunity, Innate,
pubmed-meshheading:18086835-Immunoglobulin Fc Fragments,
pubmed-meshheading:18086835-Lung Diseases, Fungal,
pubmed-meshheading:18086835-Macrophages, Alveolar,
pubmed-meshheading:18086835-Male,
pubmed-meshheading:18086835-Membrane Proteins,
pubmed-meshheading:18086835-Mice,
pubmed-meshheading:18086835-Mice, Inbred C57BL,
pubmed-meshheading:18086835-Nerve Tissue Proteins,
pubmed-meshheading:18086835-beta-Glucans
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pubmed:year |
2008
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pubmed:articleTitle |
Dectin-1 Fc targeting of aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis.
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pubmed:affiliation |
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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