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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1992-5-21
|
| pubmed:abstractText |
89 patients with angiographically documented arteriovenous malformations were treated with helium ion Bragg peak radiation. The rate of complete angiographic obliteration 2 years after radiation was 94% in those lesions smaller than 4 cm3 (2.0 cm in diameter), 75% for those 4-25 cm3 and 39% for those larger than 25 cm3 (3.7 cm in diameter); at 3 years after radiation, the corresponding obliteration rates were 100, 95 and 70%. Major clinical complications occurred in 10 patients (8 permanent, 2 transient) between 3 and 21 months after treatment; all were in the initial stage of the protocol (higher radiation doses). 10 patients bled from residual malformation between 4 and 34 months after treatment. Seizures were improved in 63% and headaches in 68% of patients. Excellent or good clinical outcome was achieved in 94% of patients. Compared to the natural history and risks of surgery for these difficult malformations, we consider these results encouraging. Heavy-charged-particle radiation is a valuable therapy for surgically inaccessible symptomatic cerebral arteriovenous malformations. The current procedure has two disadvantages: the prolonged latent period before complete obliteration and the small risk of serious neurological complications.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1011-6125
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
36-49
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1808653-Adolescent,
pubmed-meshheading:1808653-Adult,
pubmed-meshheading:1808653-Aged,
pubmed-meshheading:1808653-Brain,
pubmed-meshheading:1808653-Cerebral Angiography,
pubmed-meshheading:1808653-Cerebral Hemorrhage,
pubmed-meshheading:1808653-Child,
pubmed-meshheading:1808653-Female,
pubmed-meshheading:1808653-Helium,
pubmed-meshheading:1808653-Humans,
pubmed-meshheading:1808653-Intracranial Arteriovenous Malformations,
pubmed-meshheading:1808653-Ions,
pubmed-meshheading:1808653-Magnetic Resonance Imaging,
pubmed-meshheading:1808653-Male,
pubmed-meshheading:1808653-Middle Aged,
pubmed-meshheading:1808653-Postoperative Complications,
pubmed-meshheading:1808653-Radiosurgery,
pubmed-meshheading:1808653-Stereotaxic Techniques,
pubmed-meshheading:1808653-Tomography, X-Ray Computed
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Stereotactic helium ion Bragg peak radiosurgery for intracranial arteriovenous malformations. Detailed clinical and neuroradiologic outcome.
|
| pubmed:affiliation |
Department of Neurosurgery, Stanford University School of Medicine, Calif.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|