Linked Life Data

18084848

Source:http://linkedlifedata.com/resource/pubmed/id/18084848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-12-17
pubmed:abstractText
The association between the aqueous humour levels of asymmetric dimethylarginine (ADMA) and pigment epithelium-derived factor (PEDF) was evaluated. Aqueous humour levels of ADMA and PEDF were measured by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively, in 31 uveitis samples and nine cataract control samples. Aqueous humour ADMA and PEDF levels were significantly higher in infectious and non-infectious uveitis patients than in controls (0.67+/-0.04 nmol/ml and 0.55+/-0.03 nmol/ml versus 0.43+/-0.04 nmol/ml for ADMA; 8.22+/-1.45 microg/ml and 5.22+/-0.95 microg/ml versus 1.32+/-0.22 microg/ml for PEDF). A significant positive correlation between ADMA and PEDF levels in aqueous humour was found in control and uveitis patients. These results demonstrated that the aqueous humour level of ADMA is correlated with PEDF in humans and suggest that both ADMA and PEDF in aqueous humour may be elevated in response to inflammation in uveitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-0605
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
892-5
pubmed:meshHeading
pubmed:articleTitle
Aqueous humour levels of asymmetric dimethylarginine (ADMA) are correlated with pigment epithelium-derived factor (PEDF) in patients with uveitis.
pubmed:affiliation
Department of Ophthalmology, Kurume University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't