Linked Life Data

18083942

Source:http://linkedlifedata.com/resource/pubmed/id/18083942

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-12-17
pubmed:abstractText
Aging is a process whereby organisms lose to the capacity to effectively handle life's stresses. Associated with aging are pathophysiological processes, such as decreases in bone mass, which in the extreme form lead to significant morbidity. Evolutionary theory suggests that these pathophysiological processes are permitted to occur because an organism need only preserve its body against stress only for the amount of time needed for effective reproduction. In this review, an understanding of osteoporosis and bone loss is discussed within the context of aging theory. Specific topics covered include: (1) bone loss as an antagonistically pleiotropic physiological process, (2) age-associated stress accumulation and its negative impact on bone turnover, and (3) the mechanisms whereby gonadal failure, increases in inflammatory cytokines, and cellular bone marrow changes lead to bone loss. This review concludes by examining purported hypotheses in the context of Werner's syndrome, a disease characterized by premature aging. We suggest that future osteoporosis therapy will likely focus on prevention of aging in general as a means to prevent the development of osteoporosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-506
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Evolution, aging, and osteoporosis.
pubmed:affiliation
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't