Source:http://linkedlifedata.com/resource/pubmed/id/18083525
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2008-2-22
|
pubmed:abstractText |
Multiply deprotonated hexadeoxyadenylate anions, (A6-nH)(n-), where n = 3-5, have been subjected to reaction with a range of divalent transition-metal complex cations in the gas phase. The cations studied included the bis- and tris-1,10-phenanthroline complexes of CuII, FeII, and CoII, as well as the tris-1,10-phenanthroline complex of RuII. In addition, the hexadeoxyadenylate anions were subjected to reaction with the singly charged FeIII and CoIIIN,N'-ethylenebis(salicylideneiminato) complexes. The major competing reaction channels are electron-transfer from the oligodeoxynucleotide anion to the cation, the formation of a complex between the anion and cation, and the incorporation of the transition-metal into the oligodeoxynucleotide. The latter process proceeds via the anion/cation complex and involves displacement of the ligand(s) in the transition-metal complex by the oligodeoxynucleotide. Competition between the various reaction channels is governed by the identity of the transition-metal cation, the coordination environment of the metal complex, and the oligodeoxynucleotide charge state. In the case of the divalent metal phenanthroline complexes, competition between electron-transfer and metal ion incorporation is particularly sensitive to the coordination number of the reagent metal complexes. Both electron-transfer and metal ion incorporation occur to significant extents with the bis-phenanthroline ions, whereas the tris-phenanthroline ions react predominantly by metal ion incorporation. To our knowledge this work reports the first observations of the gas-phase incorporation of multivalent transition-metal cations into oligodeoxynucleotide anions and represents a means for the selective incorporation of transition-metal counter-ions into gaseous oligodeoxynucleotides.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylenediamines,
http://linkedlifedata.com/resource/pubmed/chemical/Gases,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Metals,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Ruthenium,
http://linkedlifedata.com/resource/pubmed/chemical/disalicylaldehyde ethylenediamine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1044-0305
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
281-93
|
pubmed:meshHeading |
pubmed-meshheading:18083525-Anions,
pubmed-meshheading:18083525-Cobalt,
pubmed-meshheading:18083525-Copper,
pubmed-meshheading:18083525-Ethylenediamines,
pubmed-meshheading:18083525-Gases,
pubmed-meshheading:18083525-Iron,
pubmed-meshheading:18083525-Metals,
pubmed-meshheading:18083525-Models, Chemical,
pubmed-meshheading:18083525-Oligodeoxyribonucleotides,
pubmed-meshheading:18083525-Ruthenium,
pubmed-meshheading:18083525-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:18083525-Spectrometry, Mass, Matrix-Assisted Laser...
|
pubmed:year |
2008
|
pubmed:articleTitle |
Gas-phase ion/ion reactions of transition metal complex cations with multiply charged oligodeoxynucleotide anions.
|
pubmed:affiliation |
School of Chemistry, University of Melbourne, Melbourne, Australia.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|