| pubmed-article:18083224 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0019134 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0808080 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C0443254 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C1705922 | lld:lifeskim |
| pubmed-article:18083224 | lifeskim:mentions | umls-concept:C1832069 | lld:lifeskim |
| pubmed-article:18083224 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18083224 | pubmed:dateCreated | 2008-1-21 | lld:pubmed |
| pubmed-article:18083224 | pubmed:abstractText | Demineralized bone matrix (DBM) is a collagen-based scaffold, but its low mechanical strength and limited BMP-2 binding ability restrict its application in bone repair. It is known that heparin could be immobilized onto scaffolds to enhance their binding of growth factors with the heparin-binding domain. Here, we crosslinked heparin to DBM to increase its BMP-2 binding ability. To our surprise, the mechanical strength of DBM was also dramatically increased. The compression modulus of heparin crosslinked DBM (HC-DBM) have improved (seven-fold increased) under wet condition, which would allow the scaffolds to keep specific shapes in vivo. As expected, HC-DBM showed specific binding ability to BMP-2. Additional studies showed the bound BMP-2 exerted its function to induce cell differentiation on the scaffold. Subcutaneous implantation of HC-DBM carrying BMP-2 showed higher alkaline phosphatase (ALP) activity (2 weeks), more calcium deposition (4 and 8 weeks) and more bone formation than that of control groups. It is concluded that HC-DBM has increased mechanical intensity as well as specific BMP-2 binding ability; HC-DBM/BMP-2 enhances the osteogenesis and therefore could be an effective medical device for bone repair. | lld:pubmed |
| pubmed-article:18083224 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18083224 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18083224 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18083224 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18083224 | pubmed:issn | 0142-9612 | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:ZhangJingJ | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:ChenBingB | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:DaiJianwuJ | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:XiaoZhifengZ | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:LinHangH | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:SunWenjieW | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:ZhaoYannanY | lld:pubmed |
| pubmed-article:18083224 | pubmed:author | pubmed-author:ZhaoWenxueW | lld:pubmed |
| pubmed-article:18083224 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18083224 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18083224 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18083224 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18083224 | pubmed:pagination | 1189-97 | lld:pubmed |
| pubmed-article:18083224 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
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| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:meshHeading | pubmed-meshheading:18083224... | lld:pubmed |
| pubmed-article:18083224 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18083224 | pubmed:articleTitle | The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. | lld:pubmed |
| pubmed-article:18083224 | pubmed:affiliation | Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing, China. | lld:pubmed |
| pubmed-article:18083224 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18083224 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18083224 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:18083224 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18083224 | lld:pubmed |
