rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-18
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pubmed:abstractText |
Hookworms infect nearly a billion people. The Ancylostoma caninum hookworm of canids is a model for studying human infections and information from its genome coupled with functional genomics and proteomics can accelerate progress towards hookworm control. As a step towards a full-scale A. caninum genome project, we generated 104,000 genome survey sequences (GSSs) and determined the genome size of the canine hookworm. GSSs assembled into 57.6 Mb of unique sequence from a genome that we estimate by flow cytometry of isolated nuclei to be 347 +/- 1.2 Mb, substantially larger than other Rhabditina species. Gene finding identified 5538 genes in the GSS assembly, for a total of 9113 non-redundant A. caninum genes when EST sequences are also considered. Functional classifications of many of the 70% of genes with homology to genes in other species are provided based on gene ontology and KEGG associations and secreted and membrane-bound proteins are also identified.
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pubmed:grant |
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18082904-8636085
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0166-6851
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pubmed:author |
pubmed-author:AbubuckerSaharS,
pubmed-author:FultonLucindaL,
pubmed-author:Hallsworth-PepinKymK,
pubmed-author:HawdonJohnJ,
pubmed-author:JohnstonJ SpencerJS,
pubmed-author:MartinJohnJ,
pubmed-author:McCarterJames PJP,
pubmed-author:MitrevaMakedonkaM,
pubmed-author:WilsonRichard KRK,
pubmed-author:YangShiaw-PyngSP,
pubmed-author:YinYongY
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-92
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pubmed:dateRevised |
2011-5-5
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences.
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pubmed:affiliation |
Department of Genetics, Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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