Linked Life Data

18081711

Source:http://linkedlifedata.com/resource/pubmed/id/18081711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-30
pubmed:abstractText
The moderating effect of early experience on gene-behavior associations has been well characterized. The molecular events that allow for such moderation are not well understood, however. We assessed the impact of early experience and serotonin transporter linked promoter polymorphism (rh5-HTTLPR) genotype on peripheral serotonin transporter (5-HTT) regulation in response to a maternal/social separation and relocation stressor in infant rhesus macaques. We further tested the hypothesis that modulation of 5-HTT regulation by rearing and/or genotype is mediated by glucocorticoid (GC) availability. Fifty-three infant (3-4 months of age) rhesus macaques that were either nursery reared (NR) or mother reared (MR) were genotyped for rh5-HTTLPR. Infants were blood sampled within 2.5 h of maternal or social separation/relocation and again 5 h later. Infants were then administered dexamethasone, a synthetic GC and blood sampled 16.5 h later. 5-HTT RNA was quantified from peripheral blood mononuclear cells. Plasma cortisol was measured at all time points. The MR individuals upregulated 5-HTT significantly during maternal/social separation, while NR individuals did not. Concomitant increases in cortisol were not observed, but dexamethasone treatment stimulated 5-HTT expression regardless of genotype/rearing group, and 5-HTT expression in the post-stressor sample was correlated with plasma cortisol levels at all time points. Our data indicate that early experience exerted a strong influence on 5-HTT regulation during a stressor in infant rhesus macaques independent of rh5-HTTLPR genotype. We also showed that GCs may stimulate 5-HTT expression but that there likely exist faster-acting transcriptional regulators of 5-HTT that are in place as a function of experience.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1601-183X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18081711-Animals, pubmed-meshheading:18081711-Brain, pubmed-meshheading:18081711-Brain Chemistry, pubmed-meshheading:18081711-Dexamethasone, pubmed-meshheading:18081711-Environment Design, pubmed-meshheading:18081711-Female, pubmed-meshheading:18081711-Genetic Variation, pubmed-meshheading:18081711-Genotype, pubmed-meshheading:18081711-Glucocorticoids, pubmed-meshheading:18081711-Hydrocortisone, pubmed-meshheading:18081711-Macaca mulatta, pubmed-meshheading:18081711-Male, pubmed-meshheading:18081711-Maternal Deprivation, pubmed-meshheading:18081711-Polymorphism, Genetic, pubmed-meshheading:18081711-Promoter Regions, Genetic, pubmed-meshheading:18081711-Serotonin, pubmed-meshheading:18081711-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:18081711-Social Isolation, pubmed-meshheading:18081711-Stress, Psychological, pubmed-meshheading:18081711-Up-Regulation
pubmed:year
2008
pubmed:articleTitle
Effects of early experience and genotype on serotonin transporter regulation in infant rhesus macaques.
pubmed:affiliation
Department of Psychology, and California National Primate Research Center, School of Veterinary Medicine, University of California Davis, Davis, CA, USA. ek2500@columbia.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural