Linked Life Data

18081182

Source:http://linkedlifedata.com/resource/pubmed/id/18081182

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-1-8
pubmed:abstractText
Neuronal oscillations have been suggested to play an important role in information processing in the brain. Using spectral analysis, we have recently shown that the repetitive burst-like firing in many dopamine (DA) neurons in the ventral tegmental area (VTA) can be described as a slow oscillation (SO) in firing rate. In this study, we examined whether DA neurons in the adjacent substantia nigra (SN) also display a SO. DA neurons were recorded extracellularly using the cells/track technique in chloral hydrate-anesthetized rats. Spectral analysis showed that firing patterns of SN DA neurons exhibited a SO similar to that observed in VTA DA neurons. The amplitude of the SO, however, was much reduced in the SN compared with that in the VTA and so was the number of DA neurons qualified as high-SO cells. In high-SO DA neurons, the amplitude of the SO was strongly correlated with the degree of bursting, and this correlation was observed in both the VTA and SN. In low-SO cells, however, the SO was more significantly correlated with the variability of firing than with firing rate and bursting. Since the generation of the SO depends on afferent inputs to DA neurons, a better understanding of its difference between the SN and VTA may provide important insights into the neural networks that control DA neurons in the two areas.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0887-4476
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-75
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Oscillatory firing of dopamine neurons: differences between cells in the substantia nigra and ventral tegmental area.
pubmed:affiliation
Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural