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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Studies in animals and patients indicate that rapamycin affects vasodilatation differently in outer and inner curvatures of blood vessels. We evaluated in this study whether rapamycin affects endothelial nitric oxide synthase (eNOS) responsiveness to shear stress under normo- and hypercholesteraemic conditions to explain these findings.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiovascular Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/enhanced green fluorescent protein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-6363
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pubmed:author |
pubmed-author:ChengCarolineC,
pubmed-author:GijsenFrankF,
pubmed-author:HaitsmaDavid BDB,
pubmed-author:HeldermanFrankF,
pubmed-author:KramsRobR,
pubmed-author:OostlanderAngelaA,
pubmed-author:SerruysPatrick WPW,
pubmed-author:TempelDennieD,
pubmed-author:WentzelJolandaJ,
pubmed-author:de CromRiniR,
pubmed-author:van HaperenRienR,
pubmed-author:van der SteenAnton F WAF
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-9
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pubmed:meshHeading |
pubmed-meshheading:18079107-Animals,
pubmed-meshheading:18079107-Apolipoproteins E,
pubmed-meshheading:18079107-Cardiovascular Agents,
pubmed-meshheading:18079107-Carotid Arteries,
pubmed-meshheading:18079107-Carotid Artery Diseases,
pubmed-meshheading:18079107-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:18079107-Disease Models, Animal,
pubmed-meshheading:18079107-Dose-Response Relationship, Drug,
pubmed-meshheading:18079107-Endothelium, Vascular,
pubmed-meshheading:18079107-Female,
pubmed-meshheading:18079107-Green Fluorescent Proteins,
pubmed-meshheading:18079107-Humans,
pubmed-meshheading:18079107-Hypercholesterolemia,
pubmed-meshheading:18079107-Male,
pubmed-meshheading:18079107-Mice,
pubmed-meshheading:18079107-Mice, Inbred C57BL,
pubmed-meshheading:18079107-Mice, Knockout,
pubmed-meshheading:18079107-Mice, Transgenic,
pubmed-meshheading:18079107-Microscopy, Confocal,
pubmed-meshheading:18079107-Nitric Oxide Synthase Type III,
pubmed-meshheading:18079107-Pulsatile Flow,
pubmed-meshheading:18079107-Recombinant Fusion Proteins,
pubmed-meshheading:18079107-Sirolimus,
pubmed-meshheading:18079107-Stress, Mechanical
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pubmed:year |
2008
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pubmed:articleTitle |
Rapamycin modulates the eNOS vs. shear stress relationship.
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pubmed:affiliation |
Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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