| pubmed-article:18078453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0025219 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C1137274 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C1512584 | lld:lifeskim |
| pubmed-article:18078453 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18078453 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18078453 | pubmed:dateCreated | 2007-12-14 | lld:pubmed |
| pubmed-article:18078453 | pubmed:abstractText | Melatonin diminishes insulin release through the activation of MT1 receptors and a reduction in cAMP production in isolated pancreatic islets of neonate and adult rats and in INS-1 cells (an insulin-secreting cell line). The pancreas of pinealectomized rats exhibits degenerative pathological changes with low islet density, indicating that melatonin plays a role to ensure the functioning of pancreatic beta cells. By using immunoprecipitation and immunoblotting analysis we demonstrated, in isolated rat pancreatic islets, that melatonin induces insulin growth factor receptor (IGF-R) and insulin receptor (IR) tyrosine phosphorylation and mediates the activities of the PI3K/AKT and MEK/ERKs pathways, which are involved in cell survival and growth, respectively. Thus, the effects of melatonin on pancreatic islets do not involve a reduction in cAMP levels only. This indoleamine may regulate growth and differentiation of pancreatic islets by activating IGF-I and insulin receptor signaling pathways. | lld:pubmed |
| pubmed-article:18078453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18078453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18078453 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18078453 | pubmed:issn | 0742-3098 | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:CuriRR | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:Cipolla-NetoJ... | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:CarpinelliA... | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:HirataA EAE | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:PicinatoM CMC | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:CarvalhoC R... | lld:pubmed |
| pubmed-article:18078453 | pubmed:author | pubmed-author:AnhêG FGF | lld:pubmed |
| pubmed-article:18078453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18078453 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:18078453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18078453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18078453 | pubmed:pagination | 88-94 | lld:pubmed |
| pubmed-article:18078453 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:meshHeading | pubmed-meshheading:18078453... | lld:pubmed |
| pubmed-article:18078453 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18078453 | pubmed:articleTitle | Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets. | lld:pubmed |
| pubmed-article:18078453 | pubmed:affiliation | Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. | lld:pubmed |
| pubmed-article:18078453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18078453 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:18078453 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18078453 | lld:pubmed |
