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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-14
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pubmed:abstractText |
Melatonin diminishes insulin release through the activation of MT1 receptors and a reduction in cAMP production in isolated pancreatic islets of neonate and adult rats and in INS-1 cells (an insulin-secreting cell line). The pancreas of pinealectomized rats exhibits degenerative pathological changes with low islet density, indicating that melatonin plays a role to ensure the functioning of pancreatic beta cells. By using immunoprecipitation and immunoblotting analysis we demonstrated, in isolated rat pancreatic islets, that melatonin induces insulin growth factor receptor (IGF-R) and insulin receptor (IR) tyrosine phosphorylation and mediates the activities of the PI3K/AKT and MEK/ERKs pathways, which are involved in cell survival and growth, respectively. Thus, the effects of melatonin on pancreatic islets do not involve a reduction in cAMP levels only. This indoleamine may regulate growth and differentiation of pancreatic islets by activating IGF-I and insulin receptor signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Melatonin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melatonin, MT1,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0742-3098
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88-94
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18078453-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18078453-Animals,
pubmed-meshheading:18078453-Female,
pubmed-meshheading:18078453-Insulin,
pubmed-meshheading:18078453-Insulin Receptor Substrate Proteins,
pubmed-meshheading:18078453-Insulin-Like Growth Factor I,
pubmed-meshheading:18078453-Islets of Langerhans,
pubmed-meshheading:18078453-MAP Kinase Signaling System,
pubmed-meshheading:18078453-Melatonin,
pubmed-meshheading:18078453-Phosphorylation,
pubmed-meshheading:18078453-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:18078453-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18078453-Rats,
pubmed-meshheading:18078453-Receptor, IGF Type 1,
pubmed-meshheading:18078453-Receptor, Insulin,
pubmed-meshheading:18078453-Receptor, Melatonin, MT1,
pubmed-meshheading:18078453-STAT3 Transcription Factor
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pubmed:year |
2008
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pubmed:articleTitle |
Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets.
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pubmed:affiliation |
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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