Linked Life Data

18078433

Source:http://linkedlifedata.com/resource/pubmed/id/18078433

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-12-14
pubmed:abstractText
We previously identified a novel endogenous substance, serofendic acid, from a lipophilic extract of fetal calf serum. The compound, a low-molecular-weight sulfur-containing atisane-type diterpenoid, exhibited potent protective action against neurotoxicity induced by glutamate, nitric oxide, and oxidant stress. We investigated whether this substance has a cardioprotective effect. Primary cultures of neonatal rat cardiac myocytes were exposed to oxidant stress (H2O2) to induce cell death. Pretreatment with serofendic acid significantly suppressed cell death induced by H2O2, and the cytoprotective effect was closely associated with the preservation of mitochondrial function. Serofendic acid inhibited H2O2-induced loss of mitochondrial membrane potential in a concentration-dependent manner (with saturation by 100 microM), by attenuating matrix calcium overload and intracellular accumulation of reactive oxygen species. The protective effect of serofendic acid was comparable to that of a mitochondrial ATP-sensitive potassium (mitoK ATP) channel opener, diazoxide. Furthermore, mitoK ATP channel blocker, 5-hydroxydecanoate, abolished the protective effect of serofendic acid. Serofendic acid and diazoxide, administered together, at 100 microM each, had no additive effects. Thus, serofendic acid inhibited the oxidant-induced mitochondrial death pathway, presumably through activation of the mitoK(ATP) channel. In conclusion, serofendic acid appears to protect cardiac myocytes from oxidant-induced cell death by preserving the functional integrity of mitochondria. Our findings suggest that serofendic acid may represent a novel candidate for cardioprotective therapy in ischemia/reperfusion injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0897-5957
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-41
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection.
pubmed:affiliation
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. akao@kuhp.kyoto-u.ac.jp
pubmed:publicationType
Journal Article, Review