Source:http://linkedlifedata.com/resource/pubmed/id/18077190
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2008-4-14
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| pubmed:abstractText |
Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counteracted by repeated short periods of maternal separation (MS). Wistar rat pups submitted to TS were handled and marked transiently per day during postnatal days 2-9 or 10-17. TS/MS pups were stimulated in the same way as TS pups and then individually separated from their mother for 1h/day. Their nontactile stimulated (NTS) siblings served as controls. In adulthood, TS and TS/MS rats showed better performance in two versions of the delayed alternation task and superior in vivo long-term potentiation of the hippocampo-prefrontal cortical pathway when compared with controls. Furthermore, there were more doses of A77636 (a selective dopamine D1 agonist) to significantly improve SWM performance in TS and TS/MS rats than in NTS rats, suggesting that activation of prefrontal D1 receptors in TS and TS/MS rats is more optimal for SWM function than in NTS rats. MS did not counteract TS-induced effects because no significant difference was found between TS/MS and TS animals. These data indicate that in early life, external tactile stimulation leads to long-term facilitative effects in SWM-related neural function.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/A 77636,
http://linkedlifedata.com/resource/pubmed/chemical/Adamantane,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1095-9564
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
89
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
397-406
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| pubmed:meshHeading |
pubmed-meshheading:18077190-Adamantane,
pubmed-meshheading:18077190-Age Factors,
pubmed-meshheading:18077190-Animals,
pubmed-meshheading:18077190-Animals, Newborn,
pubmed-meshheading:18077190-Benzopyrans,
pubmed-meshheading:18077190-Body Weight,
pubmed-meshheading:18077190-Discrimination Learning,
pubmed-meshheading:18077190-Dopamine Agonists,
pubmed-meshheading:18077190-Environment,
pubmed-meshheading:18077190-Female,
pubmed-meshheading:18077190-Habituation, Psychophysiologic,
pubmed-meshheading:18077190-Long-Term Potentiation,
pubmed-meshheading:18077190-Male,
pubmed-meshheading:18077190-Maternal Deprivation,
pubmed-meshheading:18077190-Memory, Short-Term,
pubmed-meshheading:18077190-Neuronal Plasticity,
pubmed-meshheading:18077190-Prefrontal Cortex,
pubmed-meshheading:18077190-Pregnancy,
pubmed-meshheading:18077190-Rats,
pubmed-meshheading:18077190-Rats, Wistar,
pubmed-meshheading:18077190-Receptors, Dopamine D1,
pubmed-meshheading:18077190-Space Perception,
pubmed-meshheading:18077190-Touch
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| pubmed:year |
2008
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| pubmed:articleTitle |
Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats.
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| pubmed:affiliation |
Division of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang East Road, Kunming, Yunnan 650223, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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