Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-2-25
pubmed:abstractText
Obsessive-compulsive disorder (OCD) represents a highly prevalent and impairing psychiatric disorder. Functional and structural imaging studies implicate the involvement of basal ganglia-thalamo-cortical circuits in the pathophysiology of this disorder. In patients remaining resistant to pharmaco- and behavioral therapy, modulation of these circuits may consequently reverse clinical symptoms. High frequency stimulation (HFS) of the subthalamic nucleus (STN), an important station of the basal ganglia-thalamo-cortical circuits, has been reported to reduce obsessive-compulsive symptoms in a few Parkinson's disease patients with comorbid OCD. The present study tested the effects of bilateral HFS of the STN and of bilateral pharmacological inactivation of the STN (via intracranial administration of the GABA agonist muscimol) on checking behavior in the quinpirole rat model of OCD. We demonstrate that both HFS and pharmacological inactivation of the STN reduce quinpirole-induced compulsive checking behavior. We conclude that functional inhibition of the STN can alleviate compulsive checking, and suggest the STN as a potential target structure for HFS in the treatment of OCD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-28
pubmed:meshHeading
pubmed-meshheading:18076877-Analysis of Variance, pubmed-meshheading:18076877-Animals, pubmed-meshheading:18076877-Behavior, Animal, pubmed-meshheading:18076877-Compulsive Behavior, pubmed-meshheading:18076877-Disease Models, Animal, pubmed-meshheading:18076877-Dose-Response Relationship, Drug, pubmed-meshheading:18076877-Dose-Response Relationship, Radiation, pubmed-meshheading:18076877-Drug Administration Routes, pubmed-meshheading:18076877-Electric Stimulation, pubmed-meshheading:18076877-Exploratory Behavior, pubmed-meshheading:18076877-GABA Agonists, pubmed-meshheading:18076877-Locomotion, pubmed-meshheading:18076877-Male, pubmed-meshheading:18076877-Muscimol, pubmed-meshheading:18076877-Quinpirole, pubmed-meshheading:18076877-Rats, pubmed-meshheading:18076877-Rats, Wistar, pubmed-meshheading:18076877-Subthalamic Nucleus
pubmed:year
2008
pubmed:articleTitle
High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats.
pubmed:affiliation
Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Germany; Department of Neurology, Charité Campus Mitte, Germany. christine.winter@charite.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't