Linked Life Data

18076369

Source:http://linkedlifedata.com/resource/pubmed/id/18076369

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-13
pubmed:abstractText
The sigma1 receptor is an intracellular molecule that shares no homology with any mammalian proteins. sigma1 receptors normally localize at the endoplasmic reticulum and regulate a variety of signal transductions including intracellular Ca2+ dynamics and neurotrophic factor signaling. In the brain, sigma1 receptors are known to regulate the activity of diverse ion channels via protein-protein interactions. Accumulated evidences strongly indicate that the activation/upregulation of sigma1 receptors promotes the neuronal differentiation as well as a robust antiapoptotic action. In animals, sigma1 receptor agonists exhibit an antidepressant-like action. Furthermore, the agonists enhanced neuronal survival eventhough they were administered several hours after a brain ischemia. Thus, primary clinical targets of sigma1 receptor ligands are proposed to include stroke, neurodegenerative disorders and depression. Ligands for the sigma1 receptor may constitute a new class of therapeutic drugs targeting an endoplasmic reticular protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1744-7631
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-58
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand.
pubmed:affiliation
IRP, NIDA-NIH, Cellular Pathobiology Unit, Development and Plasticity Section, Cellular Neurobiology Research Branch, Room 3418, Triad building, 333 Cassell Drive, Baltimore, MD 21224, USA. thayashi@intra.nida.nih.gov
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Intramural