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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-12-13
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pubmed:abstractText |
Administration of the beta-adrenergic receptor blocker carvedilol to patients with chronic heart failure leads to clinically significant benefits, including improvement in left ventricular systolic function in some, but not all, patients. We sought to determine the basis of the variable effect obtained with carvedilol in patients with heart failure. Carvedilol blocks both beta1-adrenergic and beta2-adrenergic receptors, and both receptors exist as polymorphisms. We aimed to determine whether these polymorphisms contribute to variability in response to carvedilol in patients with chronic heart failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1744-6872
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pubmed:author |
pubmed-author:AthertonJohnJ,
pubmed-author:BurstowDarrylD,
pubmed-author:ChenLuL,
pubmed-author:FongKwun MKM,
pubmed-author:GalbraithAndrew JAJ,
pubmed-author:JavorskyGeorgeG,
pubmed-author:LolekhaPakornP,
pubmed-author:LucasMargaretM,
pubmed-author:MeyersDeborahD,
pubmed-author:MolenaarPeterP,
pubmed-author:ParsonageWilliam AWA,
pubmed-author:SavarimuthuSantiyagu MSM,
pubmed-author:SemmlerAnnalese B TAB,
pubmed-author:YangIan AIA
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
941-9
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pubmed:meshHeading |
pubmed-meshheading:18075464-Adrenergic beta-Antagonists,
pubmed-meshheading:18075464-Carbazoles,
pubmed-meshheading:18075464-Cardiomyopathy, Dilated,
pubmed-meshheading:18075464-Echocardiography,
pubmed-meshheading:18075464-Female,
pubmed-meshheading:18075464-Genotype,
pubmed-meshheading:18075464-Humans,
pubmed-meshheading:18075464-Male,
pubmed-meshheading:18075464-Middle Aged,
pubmed-meshheading:18075464-Pharmacogenetics,
pubmed-meshheading:18075464-Polymorphism, Genetic,
pubmed-meshheading:18075464-Propanolamines,
pubmed-meshheading:18075464-Receptors, Adrenergic, beta-1,
pubmed-meshheading:18075464-Systole,
pubmed-meshheading:18075464-Ventricular Function, Left
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pubmed:year |
2007
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pubmed:articleTitle |
Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol.
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pubmed:affiliation |
Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia. lchen@somc.uq.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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