Source:http://linkedlifedata.com/resource/pubmed/id/18072270
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2008-1-24
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pubmed:abstractText |
Schwannomatosis is characterized by the onset of multiple intracranial, spinal, or peripheral schwannomas, without involvement of the vestibular nerve, which is instead pathognomonic of neurofibromatosis type 2 (NF2). Recently, a schwannomatosis family with a germline mutation of the SMARCB1 gene on chromosome 22 has been described. We report on the molecular analysis of the SMARCB1 and NF2 genes in a series of 21 patients with schwannomatosis and in eight schwannomatosis-associated tumors from four different patients. A novel germline SMARCB1 mutation was found in one patient; inactivating somatic mutations of NF2, associated with loss of heterozygosity (LOH) of 22q, were found in two schwannomas of this patient. This is the second report of a germline SMARCB1 mutation in patients affected by schwannomatosis and the first report of SMARCB1 mutations associated with somatic NF2 mutations in schwannomatosis-associated tumors. The latter observation suggests that a four-hit mechanism involving the SMARCB1 and NF2 genes may be implicated in schwannomatosis-related tumorigenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofibromin 2,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1098-1004
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-31
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pubmed:meshHeading |
pubmed-meshheading:18072270-Adult,
pubmed-meshheading:18072270-Base Sequence,
pubmed-meshheading:18072270-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:18072270-DNA Mutational Analysis,
pubmed-meshheading:18072270-DNA-Binding Proteins,
pubmed-meshheading:18072270-Female,
pubmed-meshheading:18072270-Humans,
pubmed-meshheading:18072270-Loss of Heterozygosity,
pubmed-meshheading:18072270-Male,
pubmed-meshheading:18072270-Middle Aged,
pubmed-meshheading:18072270-Molecular Sequence Data,
pubmed-meshheading:18072270-Mutation,
pubmed-meshheading:18072270-Neurilemmoma,
pubmed-meshheading:18072270-Neurofibromin 2,
pubmed-meshheading:18072270-Peripheral Nervous System Neoplasms,
pubmed-meshheading:18072270-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas.
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pubmed:affiliation |
Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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