Source:http://linkedlifedata.com/resource/pubmed/id/18071345
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-4-14
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pubmed:abstractText |
Previous studies suggested that polymorphisms in the coding region of the preproghrelin were involved in the etiology of obesity and might modulate glucose-induced insulin secretion. We evaluated the association of a new variation, -604C>T, in the promoter region of the ghrelin gene, of Leu72Met (247C>A) and of Gln90Leu (265A>T), all haplotype-tagging single nucleotide polymorphisms (SNPs), with measures of insulin sensitivity in 1420 adult individuals.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1476-5497
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18071345-Adult,
pubmed-meshheading:18071345-Gene Frequency,
pubmed-meshheading:18071345-Genetic Predisposition to Disease,
pubmed-meshheading:18071345-Ghrelin,
pubmed-meshheading:18071345-Haplotypes,
pubmed-meshheading:18071345-Humans,
pubmed-meshheading:18071345-Insulin,
pubmed-meshheading:18071345-Insulin Resistance,
pubmed-meshheading:18071345-Linkage Disequilibrium,
pubmed-meshheading:18071345-Middle Aged,
pubmed-meshheading:18071345-Polymorphism, Single Nucleotide,
pubmed-meshheading:18071345-Promoter Regions, Genetic,
pubmed-meshheading:18071345-Triglycerides
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pubmed:year |
2008
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pubmed:articleTitle |
A new variation in the promoter region, the -604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance.
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pubmed:affiliation |
Endocrinology, Department of Clinical Sciences, University of Rome Sapienza, Polo Pontino, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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