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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-12-25
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pubmed:databankReference |
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pubmed:abstractText |
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats and that the duplication is mediated somatically by homologous recombination between the flanking Alu elements on sister chromatids. Nested long-range PCR analysis indicated a low frequency of homologous recombination leading to MYB tandem duplication in the peripheral blood mononuclear cells of approximately 50% of healthy individuals, none of whom had a MYB duplication in the germline. We conclude that Alu-mediated MYB tandem duplication occurs at low frequency during normal thymocyte development and is clonally selected during the molecular pathogenesis of human T-ALL.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-10323859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-10381326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-11034064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-11080157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-11988762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-12185367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-12941699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-1461655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-15195090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-15256441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-15334549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-15466706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-15472075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-16166372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-16597594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-1680958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-16815104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-16847353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-16954387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-17114293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-17435759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-17452517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-17515920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-2354420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-2832742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-6289315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-6297766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-6589609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-7475267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-8950988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-9353180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-9482895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070937-9915971
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1540-9538
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pubmed:author |
pubmed-author:ChinLyndaL,
pubmed-author:DeAngeloDaniel JDJ,
pubmed-author:DePinhoRonald ARA,
pubmed-author:FengBinB,
pubmed-author:FuY PYP,
pubmed-author:GutierrezAlejandroA,
pubmed-author:KutokJeffery LJL,
pubmed-author:LeeCharlesC,
pubmed-author:LiuX ShirleyXS,
pubmed-author:LookA ThomasAT,
pubmed-author:MaserRichard SRS,
pubmed-author:McKennaKeithK,
pubmed-author:MoreauLisaL,
pubmed-author:NeubergDonnaD,
pubmed-author:O'NeilJenniferJ,
pubmed-author:RothsteinRodneyR,
pubmed-author:SilvermanLewisL,
pubmed-author:TchindaJoelleJ,
pubmed-author:WongKwok-KinKK
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3059-66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18070937-Alu Elements,
pubmed-meshheading:18070937-Base Sequence,
pubmed-meshheading:18070937-Gene Duplication,
pubmed-meshheading:18070937-Humans,
pubmed-meshheading:18070937-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18070937-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:18070937-Models, Biological,
pubmed-meshheading:18070937-Models, Genetic,
pubmed-meshheading:18070937-Molecular Sequence Data,
pubmed-meshheading:18070937-Nucleic Acid Hybridization,
pubmed-meshheading:18070937-Polymerase Chain Reaction,
pubmed-meshheading:18070937-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:18070937-Recombination, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
Alu elements mediate MYB gene tandem duplication in human T-ALL.
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pubmed:affiliation |
Department of Pediatric Oncology, Belfer Foundation Institute for Innovative Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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