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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-12
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pubmed:abstractText |
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * In recent years, it has been suggested that hair follicles represent important shunt routes into the skin for drugs and chemicals [1-3]. * In vitro studies have shown the importance of skin appendages for skin penetration by hydrophilic compounds [4]. Investigation of follicular penetration in vivo has been difficult due to the absence of appropriate analytical methods or suitable animal model systems. * Recently, a new method was described that quantifies follicular penetration in vivo by using selective closure of hair follicles [5]. * Caffeine is frequently used in skin penetration experiments as a model for highly water-soluble compounds. Occlusion [6] and skin thickness [7] seem to have little influence on the penetration of caffeine. However, percutaneous absorption rates for caffeine exhibit regional skin differences in humans in vivo[1].
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-10434134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-10461093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-10536254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-11093635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-11576769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-12495550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-14962084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15236454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15256477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15568130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15681080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15817611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-15862696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-1637558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-16435152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-16679824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-17214716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-2128017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-2445192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-3625489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-3789805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-3961793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-4297098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-5123154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-6020682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-6854051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-8054206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18070215-8773963
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2125
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
488-92
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pubmed:dateRevised |
2011-1-11
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pubmed:meshHeading |
pubmed-meshheading:18070215-Administration, Cutaneous,
pubmed-meshheading:18070215-Adult,
pubmed-meshheading:18070215-Caffeine,
pubmed-meshheading:18070215-Central Nervous System Stimulants,
pubmed-meshheading:18070215-Drug Delivery Systems,
pubmed-meshheading:18070215-Hair Follicle,
pubmed-meshheading:18070215-Humans,
pubmed-meshheading:18070215-Male,
pubmed-meshheading:18070215-Skin Absorption,
pubmed-meshheading:18070215-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
The role of hair follicles in the percutaneous absorption of caffeine.
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pubmed:affiliation |
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Charité-Universitaetsmedizin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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