Source:http://linkedlifedata.com/resource/pubmed/id/18068982
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-1-21
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| pubmed:abstractText |
An unexpected ring contraction of benzazepinone based alpha(nu)beta(3) antagonists led to the design of quinolinone-type derivatives. Novel and efficient synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates were established. Nanomolar alpha(nu)beta(3) antagonists based on these new scaffolds were prepared. Moreover, benzoxazinones 15a and 15b exhibited high microsomal stability and good permeability.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
527-31
|
| pubmed:meshHeading |
pubmed-meshheading:18068982-Benzoxazines,
pubmed-meshheading:18068982-Drug Design,
pubmed-meshheading:18068982-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18068982-Integrin alphaVbeta3,
pubmed-meshheading:18068982-Isoquinolines,
pubmed-meshheading:18068982-Quinazolines,
pubmed-meshheading:18068982-Structure-Activity Relationship
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Design and synthesis of novel potent and selective integrin alphanubeta3 antagonists--novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates.
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| pubmed:affiliation |
BASF AG, Main Research Laboratory, D-67056 Ludwigshafen, Germany.
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| pubmed:publicationType |
Journal Article
|