Linked Life Data

18068369

Source:http://linkedlifedata.com/resource/pubmed/id/18068369

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-12-28
pubmed:abstractText
Surgical treatment of psychiatric disease can be effective for some patients with severe, intractable disorders. However, few long-term studies using comprehensive psychiatric test evaluation of patients who have undergone surgery have been carried out. Stereotactic limbic leukotomy (subcaudate tractotomy and cingulotomy) was performed via radiofrequency thermocoagulation on 16 patients with intractable major affective disorders (bipolar). Patients were followed for 7 years, and nine complete psychiatric test evaluations were conducted before and after the procedure. Clinical outcomes were evaluated using the Current Global Psychiatric-Social Status Scale (CGPSS). In the 7-year follow-up, mean scores on the Hamilton Depression Rating Scale and the Beck Depression Inventory declined significantly from 42+/-5.76 to 20+/-11.98 (p<0.01) and from 32+/-9.13 to 19 +/- 14.29 (p<0.05), respectively. Also, mean scores on the Hamilton Anxiety Rating Scale and Negative Symptom Scale declined significantly from 104+/-53.62 to 57+/-36.41 (p<0.01) and from 57+/-15.38 to 33+/-18.8 (p<0.05), respectively. There were no statistical differences before and after surgery for Young's Mania Rating Scale, p>0.1. Using the CGPSS, 68.8% of patients had a marked response (CGPSS of >or=3), 18.9% of patients had a possible response (CGPSS of 2), and 12.6% did not improve or became worse (CGPSS of 0 or 1). There was no surgical mortality and only three patients experienced temporary minor complications. Based on these nine comprehensive psychiatric test evaluations, limbic leukotomy is an effective procedure for long-term treatment of severe, intractable major affective disorders, with no significant side effects. The results of the psychiatric tests carried out during the 7 years of follow-up were constant and stable. The current findings demonstrate that depression, anxiety, and negative symptoms are significantly reduced by limbic leukotomy, but mania and active symptoms are not. Surgical intervention remains an important therapeutic option for the treatment of major affective disorders, and is probably underused.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0967-5868
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-42
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Limbic leukotomy for intractable major affective disorders: a 7-year follow-up study using nine comprehensive psychiatric test evaluations.
pubmed:affiliation
Department of Neurosurgery, China Medical University Hospital, No. 2 Yu-Der Road, Taichung, Taiwan. d5057@www.cmuh.org.tw
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial