18068156

Source:http://linkedlifedata.com/resource/pubmed/id/18068156

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0016072, umls-concept:C0086418, umls-concept:C0178576, umls-concept:C0392756, umls-concept:C0675096, umls-concept:C0871261, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C2911692
pubmed:issue	4
pubmed:dateCreated	2008-2-11
pubmed:abstractText	DNA interstrand crosslinks are processed by multiple mechanisms whose relationships to each other are unclear. Xeroderma pigmentosum-variant (XP-V) cells lacking DNA polymerase eta are sensitive to psoralen photoadducts created under conditions favoring crosslink formation, suggesting a role for translesion synthesis in crosslink repair. Because crosslinks can lead to double-strand breaks, we monitored phosphorylated H2AX (gamma-H2AX), which is typically generated near double-strand breaks but also in response to single-stranded DNA, following psoralen photoadduct formation in XP-V fibroblasts to assess whether polymerase eta is involved in processing crosslinks. In contrast to conditions favoring monoadducts, conditions favoring psoralen crosslinks induced gamma-H2AX levels in both XP-V and nucleotide excision repair-deficient XP-A cells relative to control repair-proficient cells; ectopic expression of polymerase eta in XP-V cells normalized the gamma-H2AX response. In response to psoralen crosslinking, gamma-H2AX as well as 53BP1 formed coincident foci that were more numerous and intense in XP-V and XP-A cells than in controls. Psoralen photoadducts induced gamma-H2AX throughout the cell cycle in XP-V cells. These results indicate that polymerase eta is important in responding to psoralen crosslinks, and are consistent with a model in which nucleotide excision repair and polymerase eta are involved in processing crosslinks and avoiding gamma-H2AX associated with double-strand breaks and single-stranded DNA in human cells.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA105958, http://linkedlifedata.com/resource/pubmed/grant/R01 CA105958-03, http://linkedlifedata.com/resource/pubmed/grant/R01 CA105958-04, http://linkedlifedata.com/resource/pubmed/grant/R01 CA105958-05
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0373226
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed DNA Polymerase, http://linkedlifedata.com/resource/pubmed/chemical/H2AFX protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Histones, http://linkedlifedata.com/resource/pubmed/chemical/Psoralens, http://linkedlifedata.com/resource/pubmed/chemical/Rad30 protein, http://linkedlifedata.com/resource/pubmed/chemical/psoralen-DNA adduct
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0014-4827
pubmed:author	pubmed-author:ButcherChristina ECE, pubmed-author:MogiSeikiS, pubmed-author:OhDennis HDH
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	314
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	887-95
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18068156-Cell Cycle, pubmed-meshheading:18068156-Cell Line, Transformed, pubmed-meshheading:18068156-DNA Adducts, pubmed-meshheading:18068156-DNA Breaks, Double-Stranded, pubmed-meshheading:18068156-DNA Repair, pubmed-meshheading:18068156-DNA-Directed DNA Polymerase, pubmed-meshheading:18068156-Histones, pubmed-meshheading:18068156-Humans, pubmed-meshheading:18068156-Psoralens, pubmed-meshheading:18068156-Ultraviolet Rays, pubmed-meshheading:18068156-Xeroderma Pigmentosum
pubmed:year	2008
pubmed:articleTitle	DNA polymerase eta reduces the gamma-H2AX response to psoralen interstrand crosslinks in human cells.
pubmed:affiliation	Department of Dermatology, University of California, San Francisco, and Dermatology Research Unit, San Francisco VA Medical Center 94121, USA.

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