Linked Life Data

18066846

Source:http://linkedlifedata.com/resource/pubmed/id/18066846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10-12
pubmed:dateCreated
2007-12-10
pubmed:abstractText
Novel L-bicyclocarba-d4T (1), an enantiomer of D-N-MCd4T has been enantiopurely synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, Grignard reaction, RCM reaction, and Mitsunobu reaction as key steps. L-N-MCd4T (1) was found to be very potent anti-HIV-1 (EC(50) = 6.76 microg/mL) agent with no cytotoxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1653-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Asymmetric synthesis and biological activity of L-bicyclocarba-d4T.
pubmed:affiliation
College of Pharmacy and Research Institute for Drug Development, Pusan National University, San 30 Jangjeon-dong, Geumjeong-gu, Busan 609-735, Korea. mhr108@pusan.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't