Source:http://linkedlifedata.com/resource/pubmed/id/18065961
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-1-25
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| pubmed:abstractText |
TMPRSS2-ERG gene fusion leading to the androgenic induction of the ERG proto-oncogene expression is a highly prevalent oncogenic alteration in prostate tumor cells. Prostate cancer is a multi-focal disease, and the origins as well as biological contribution of multiple cancer foci remain unclear with respect to prostate cancer onset or progression. To assess the role of TMPRSS2-ERG alteration in prostate cancer onset and/or progression, we have evaluated the status of fusion transcripts in benign glands, prostatic intraepithelial neoplasia (PIN) and multiple cancer foci of each prostate. Quantitative expression of TMPRSS2-ERG fusion type A and C transcripts was analyzed in benign, tumor and PIN areas, selected from whole-mount radical prostatectomy slides. TMPRSS2-ERG expression was correlated with clinicopathological features. Overall, 30 of 45 (67%) patients exhibited TMPRSS2-ERG fusion transcripts in at least one tumor focus. Of 80 tumor foci analyzed, 39 had TMPRSS2-ERG fusion (type A only: 30, type C only: 2, both types A and C: 7), with predominant detection of the TMPRSS2-ERG fusion type A (27/30, 90%) in the index tumors. Of 14 PIN lesions, 2 were positive for type A fusion. Frequent presence of the TMPRSS2-ERG in index tumors suggests critical roles of ERG alterations in the onset and progression of a large subset of prostate cancer. However, heterogeneity of the TMPRSS2-ERG detection in the context of multiple cancer foci and its frequency in PIN also support the role of other genomic alterations in the origins of prostate cancer.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/TMPRSS2-ERG fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0893-3952
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| pubmed:author |
pubmed-author:ChenYongmeiY,
pubmed-author:CullenJenniferJ,
pubmed-author:DobiAlbertA,
pubmed-author:FurusatoBungoB,
pubmed-author:GaoChun-LingCL,
pubmed-author:McLeodDavid GDG,
pubmed-author:PetrovicsGyorgyG,
pubmed-author:RavindranathLakshmiL,
pubmed-author:SesterhennIsabell AIA,
pubmed-author:SrivastavaShivS
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| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
67-75
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| pubmed:meshHeading |
pubmed-meshheading:18065961-Adenocarcinoma,
pubmed-meshheading:18065961-Cell Line, Tumor,
pubmed-meshheading:18065961-Disease-Free Survival,
pubmed-meshheading:18065961-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18065961-Humans,
pubmed-meshheading:18065961-Male,
pubmed-meshheading:18065961-Microdissection,
pubmed-meshheading:18065961-Middle Aged,
pubmed-meshheading:18065961-Neoplasm Recurrence, Local,
pubmed-meshheading:18065961-Oncogene Proteins, Fusion,
pubmed-meshheading:18065961-Precancerous Conditions,
pubmed-meshheading:18065961-Prostate,
pubmed-meshheading:18065961-Prostate-Specific Antigen,
pubmed-meshheading:18065961-Prostatectomy,
pubmed-meshheading:18065961-Prostatic Intraepithelial Neoplasia,
pubmed-meshheading:18065961-Prostatic Neoplasms,
pubmed-meshheading:18065961-RNA, Neoplasm,
pubmed-meshheading:18065961-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18065961-Tumor Markers, Biological
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| pubmed:year |
2008
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| pubmed:articleTitle |
Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancer.
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| pubmed:affiliation |
Department of Surgery, United States Military Cancer Institute, Center for Prostate Disease Research, Uniformed Service University of the Health Science, Bethesda, MD, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|