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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-2-25
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pubmed:abstractText |
We investigated the mechanisms of shear stress (SS)-induced activation of cytochrome P450 (CYP) 1A1 and cell cycle arrest with regard to the role of the aryl hydrocarbon receptor (AhR), since AhR mediates the expression of CYP1A1 induced by polycyclic aromatic hydrocarbons (PAHs) and is thought to be involved in the regulation of cell growth and differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AHR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-naphthoflavone
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
809-18
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18065768-Active Transport, Cell Nucleus,
pubmed-meshheading:18065768-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:18065768-Benzoflavones,
pubmed-meshheading:18065768-Cell Cycle,
pubmed-meshheading:18065768-Cells, Cultured,
pubmed-meshheading:18065768-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:18065768-Cytochrome P-450 CYP1A1,
pubmed-meshheading:18065768-Endothelial Cells,
pubmed-meshheading:18065768-Enzyme Activation,
pubmed-meshheading:18065768-Enzyme Induction,
pubmed-meshheading:18065768-Humans,
pubmed-meshheading:18065768-Mitogen-Activated Protein Kinases,
pubmed-meshheading:18065768-Phosphorylation,
pubmed-meshheading:18065768-Promoter Regions, Genetic,
pubmed-meshheading:18065768-Pulsatile Flow,
pubmed-meshheading:18065768-RNA, Messenger,
pubmed-meshheading:18065768-RNA, Small Interfering,
pubmed-meshheading:18065768-RNA Interference,
pubmed-meshheading:18065768-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:18065768-Response Elements,
pubmed-meshheading:18065768-Retinoblastoma Protein,
pubmed-meshheading:18065768-Stress, Mechanical,
pubmed-meshheading:18065768-Time Factors,
pubmed-meshheading:18065768-Transcription, Genetic,
pubmed-meshheading:18065768-Transcriptional Activation
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pubmed:year |
2008
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pubmed:articleTitle |
Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells.
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pubmed:affiliation |
Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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