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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-5-12
|
| pubmed:abstractText |
Hypochondroplasia is a skeletal dysplasia characterised by poor childhood growth and an inadequate pubertal growth spurt. 31 children with a radiological diagnosis of hypochondroplasia have been treated for up to 3 years with recombinant human growth hormone, mean dose 17.9 U/m2/week as daily subcutaneous injections. Mean pre-treatment height velocity standard deviation score (SDS) was -0.51; this increased to +1.58 after 1 year of treatment. This improvement diminishes over the next 2 years. The effect on final height remains unknown. There was a considerable variation in clinical response within the group treated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0163
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
56-60
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1806487-Adolescent,
pubmed-meshheading:1806487-Body Height,
pubmed-meshheading:1806487-Bone Diseases, Developmental,
pubmed-meshheading:1806487-Child,
pubmed-meshheading:1806487-Child, Preschool,
pubmed-meshheading:1806487-Growth Hormone,
pubmed-meshheading:1806487-Humans,
pubmed-meshheading:1806487-Recombinant Proteins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Growth of children with hypochondroplasia treated with growth hormone for up to three years.
|
| pubmed:affiliation |
Middlesex Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article
|