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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-10
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pubmed:abstractText |
In this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNgamma production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:BauerJacquesJ,
pubmed-author:ChabreHenriH,
pubmed-author:ChiavaroliCarloC,
pubmed-author:HoriotStéphaneS,
pubmed-author:LombardiVincentV,
pubmed-author:MascarellLaurentL,
pubmed-author:MoingeonPhilippeP,
pubmed-author:MoussuHélèneH,
pubmed-author:MoutelStéphaneS,
pubmed-author:RazafindratsitaAlainA,
pubmed-author:TaroyanSS,
pubmed-author:Van OvertveltLaurenceL
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
108-18
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18063445-Adjuvants, Immunologic,
pubmed-meshheading:18063445-Administration, Sublingual,
pubmed-meshheading:18063445-Animals,
pubmed-meshheading:18063445-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18063445-Cell Polarity,
pubmed-meshheading:18063445-Dendritic Cells,
pubmed-meshheading:18063445-Desensitization, Immunologic,
pubmed-meshheading:18063445-Dipeptides,
pubmed-meshheading:18063445-Female,
pubmed-meshheading:18063445-Humans,
pubmed-meshheading:18063445-Immune Tolerance,
pubmed-meshheading:18063445-Interferon-gamma,
pubmed-meshheading:18063445-Mice,
pubmed-meshheading:18063445-Mice, Inbred BALB C,
pubmed-meshheading:18063445-T-Lymphocytes, Regulatory,
pubmed-meshheading:18063445-Th1 Cells
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pubmed:year |
2007
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pubmed:articleTitle |
A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route.
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pubmed:affiliation |
Stallergènes SA, Research and Development, 6 rue Alexis de Tocqueville, 92160 Antony, France.
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pubmed:publicationType |
Journal Article
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