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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-15
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pubmed:abstractText |
Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) regulate calcium homeostasis, and PTHrP further regulates growth and development. A transgenic mouse carrying the constitutively active PTH/PTHrP receptor (HKrk-H223R) under the control of the mouse bone and odontoblast-specific alpha1(I) collagen promoter (Col1-caPPR) has been developed to demonstrate the complex actions of this mutant receptor in hard tissue formation. We have further characterized Col1-caPPR mice abnormalities in the craniofacial region as a function of development. Col1-caPPR mice exhibited a delay in embryonic bone formation, followed by expansion of a number of craniofacial bones including the maxilla and mandible, delay in tooth eruption and teratosis, and a disrupted temporomandibular joint (TMJ). These findings suggest that the Col1-caPPR mouse is a useful model for characterization of the downstream effects of the constitutively active receptor during development and growth, and as a model for development of treatments of human diseases with similar characteristics.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
8756-3282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18063434-Animals,
pubmed-meshheading:18063434-Collagen Type I,
pubmed-meshheading:18063434-Embryo, Mammalian,
pubmed-meshheading:18063434-Facial Bones,
pubmed-meshheading:18063434-Female,
pubmed-meshheading:18063434-Male,
pubmed-meshheading:18063434-Mice,
pubmed-meshheading:18063434-Mice, Transgenic,
pubmed-meshheading:18063434-Microscopy, Electron, Scanning,
pubmed-meshheading:18063434-Parathyroid Hormone,
pubmed-meshheading:18063434-Promoter Regions, Genetic,
pubmed-meshheading:18063434-Tomography, X-Ray Computed
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pubmed:year |
2008
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pubmed:articleTitle |
Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor.
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pubmed:affiliation |
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department Health Human Services, Bethesda, MD 20892, USA. ryuryu@tokyo.ndu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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