Linked Life Data

1806153

Source:http://linkedlifedata.com/resource/pubmed/id/1806153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-5-14
pubmed:abstractText
Four-month-old, ovariectomized mice were treated with 14 daily ip injections of either 10.0 micrograms of 17 beta-estradiol or 1.0 mg technical grade methoxychlor. Uterine luminal proteins were radiolabeled with 35S-methionine and run on 2-dimensional electrophoresis gels. The influence of methoxychlor or estradiol was compared to untreated controls by examining reproductive tract weights, uterine histology, and the patterns of uterine protein secretions. The data indicate that the stimulation of the uterus in ovariectomized, adult mice by methoxychlor is indistinguishable from that caused by estradiol. Both substances alter reproductive tract weights, promote cellular hypertrophy, stimulate uterine development, and induce the secretion of comparable levels of incorporation of methionine into a large number of proteins. The data further indicate that the alterations in gene expression promoted by estradiol in terms of secreted proteins appear to be qualitatively similar to those caused by the pesticide methoxychlor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0890-6238
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Protein secretions in mouse uterus after methoxychlor or estradiol exposure.
pubmed:affiliation
Department of Biological Sciences, WAMI Medical Program, University of Idaho, Moscow 83843.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't