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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-21
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pubmed:abstractText |
A series of six-six and six-five fused heterocyclic CXCR3 antagonists has been synthesized and their activities evaluated in an [(125)I]-IP-10 displacement assay and an ITAC mediated in vitro cell migration assay. The pharmacokinetic properties of several top compounds have also been studied. This effort led to the discovery of compounds with increased potency and improved pharmacokinetic properties that could serve as useful tools to study the role of the CXCR3 receptor in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BergeronPhillipeP,
pubmed-author:CarabeoTeresaT,
pubmed-author:ChenXiaoqiX,
pubmed-author:CollinsTassie LTL,
pubmed-author:DanaoJayJ,
pubmed-author:DeignanJeffreyJ,
pubmed-author:DuXiaohuiX,
pubmed-author:DuquetteJasonJ,
pubmed-author:FuZiceZ,
pubmed-author:GustinDarin JDJ,
pubmed-author:JohnsonMichael GMG,
pubmed-author:LemonBryanB,
pubmed-author:LiAn-RongAR,
pubmed-author:LiuJiwenJ,
pubmed-author:MarcusAndrew PAP,
pubmed-author:McGeeLawrence RLR,
pubmed-author:MedinaJulio CJC,
pubmed-author:MihalicJeffrey TJT,
pubmed-author:PyeS DSD,
pubmed-author:SullivanTimothyT,
pubmed-author:TangLiangL,
pubmed-author:TonnGeorgeG,
pubmed-author:ZhuLiushengL
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
18
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
688-93
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.
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pubmed:affiliation |
Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
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pubmed:publicationType |
Journal Article
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