Linked Life Data

18061279

Source:http://linkedlifedata.com/resource/pubmed/id/18061279

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-1-14
pubmed:abstractText
Two single nucleotide polymorphisms of the human BDNF gene, G196A and C270T, and their impact on the susceptibility to MS and disease progression in the Polish population were investigated. Increased risk of the disease was found for 196G/G carriers (OR -- 1.63, p=0.01) (only females) and 270C/T carriers (OR -- 7.76, p<0.001) (both males and females). The first signs of the disease appeared earlier in 196G/G than 196G/A patients (p=0.01), but it was limited to males. Our results show that C270T and G196A BDNF polymorphisms may affect susceptibility to and onset of MS, but further verification is needed, with special attention to gender differences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
193
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
170-2
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences.
pubmed:affiliation
2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland.
pubmed:publicationType
Journal Article