Source:http://linkedlifedata.com/resource/pubmed/id/18061179
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-1-1
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pubmed:abstractText |
T-cell receptor reactivity of intestinal lamina propria T cells (LP-T) critically depends on the capacity of local accessory cells to secrete cysteine. For T cells, cysteine is the limiting precursor for glutathione synthesis, a prerequisite for antigen-dependent proliferation. We aimed to determine the role of the redoxactive microenvironment for hyporeactivity of LP-T in normal human gut vs hyperreactivity of LP-T in inflammatory bowel disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-0012
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-91
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pubmed:meshHeading |
pubmed-meshheading:18061179-Case-Control Studies,
pubmed-meshheading:18061179-Cell Culture Techniques,
pubmed-meshheading:18061179-Cysteine,
pubmed-meshheading:18061179-Cystine,
pubmed-meshheading:18061179-Glutathione,
pubmed-meshheading:18061179-Humans,
pubmed-meshheading:18061179-Immunity, Mucosal,
pubmed-meshheading:18061179-Inflammatory Bowel Diseases,
pubmed-meshheading:18061179-Intestinal Mucosa,
pubmed-meshheading:18061179-RNA, Messenger,
pubmed-meshheading:18061179-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation.
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pubmed:affiliation |
Department of Surgery, Ruprecht-Karls-University, Heidelberg, Germany. brandl-sido@t-online.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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