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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-12-31
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pubmed:abstractText |
Sanguis Draconis (SD) is a kind of dragon's blood resin that is obtained from Daemomorops draco (Palmae). It is used in traditional medicine and has shown anti-inflammatory activity in some diseases. In this study, we examined the effects of Sanguis Dranonis ethanol extract (SDEE) on LPS-induced inflammation using RAW 264.7 cells. Our data indicated that SDEE inhibits LPS-stimulated NO, PGE2, IL-1 beta and TNF-alpha release, and iNOS and COX-2 expression. Furthermore, SDEE suppressed the LPS-induced p65 expression of NF-kappa B, which was associated with the inhibition of I kappa B-alpha degradation. We also found that the expression of HO-1 was significantly increased in RAW 264.7 cells by SDEE. These results suggest among possibilities of anti-inflammation that SDEE inhibits the production of NO and PGE2 by the down-regulation of iNOS and COX-2 gene expression via the suppression of NF-kappaB (p65) activation. SDEE can induce HO-1 over-expression in macrophage cells, which indicates that it may possess antioxidant properties. This result means that SEDD its anti-inflammatory effects in macrophages may be through a novel mechanism that involves the action of HO-1. Thus, SD could provide a potential therapeutic approach for inflammation-associated disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Resins, Plant
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-62
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pubmed:meshHeading |
pubmed-meshheading:18060707-Animals,
pubmed-meshheading:18060707-Anti-Inflammatory Agents,
pubmed-meshheading:18060707-Antioxidants,
pubmed-meshheading:18060707-Arecaceae,
pubmed-meshheading:18060707-Cell Line,
pubmed-meshheading:18060707-Cyclooxygenase 2,
pubmed-meshheading:18060707-Dinoprostone,
pubmed-meshheading:18060707-Gene Expression Regulation,
pubmed-meshheading:18060707-Heme Oxygenase-1,
pubmed-meshheading:18060707-Inflammation,
pubmed-meshheading:18060707-Lipopolysaccharides,
pubmed-meshheading:18060707-Macrophages,
pubmed-meshheading:18060707-Medicine, Traditional,
pubmed-meshheading:18060707-Mice,
pubmed-meshheading:18060707-Nitric Oxide,
pubmed-meshheading:18060707-Nitric Oxide Synthase Type II,
pubmed-meshheading:18060707-Plant Extracts,
pubmed-meshheading:18060707-Resins, Plant
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pubmed:year |
2008
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pubmed:articleTitle |
Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis Draconis, a dragon's blood resin, in RAW 264.7 cells.
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pubmed:affiliation |
Emergency Department of Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, ROC.
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pubmed:publicationType |
Journal Article
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