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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-3-14
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pubmed:abstractText |
A change in the serum creatinine is not sensitive for an early diagnosis of acute kidney injury. We evaluated urinary levels of matrix metalloproteinase-9 (MMP-9), N-acetyl-beta-D-glucosaminidase (NAG), and kidney injury molecule-1 (KIM-1) as biomarkers for the detection of acute kidney injury. Urine samples were collected from 44 patients with various acute and chronic kidney diseases, and from 30 normal subjects in a cross-sectional study. A case-control study of children undergoing cardio-pulmonary bypass surgery included urine specimens from each of 20 patients without and with acute kidney injury. Injury was defined as a greater than 50% increase in the serum creatinine within the first 48 h after surgery. The biomarkers were normalized to the urinary creatinine concentration at 12, 24, and 36 h after surgery with the areas under the receiver-operating characteristic curve compared for performance. In the cross-sectional study, the area under the curve for MMP-9 was least sensitive followed by KIM-1 and NAG. Combining all three biomarkers achieved a perfect score diagnosing acute kidney injury. In the case-control study, KIM-1 was better than NAG at all time points, but combining both was no better than KIM-1 alone. Urinary MMP-9 was not a sensitive marker in the case-control study. Our results suggest that urinary biomarkers allow diagnosis of acute kidney injury earlier than a rise in serum creatinine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-10075613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-11237011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-12081583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-12584277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-14600030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15075185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15234233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15616389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15744000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15811456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-15888557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-16542249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-16710348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-16931980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-17267747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-17325478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-18340352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-2901937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-3653576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-6172216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-6824004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-6878708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-9461608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059454-9853246
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1523-1755
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
863-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18059454-Acetylglucosaminidase,
pubmed-meshheading:18059454-Acute Kidney Injury,
pubmed-meshheading:18059454-Adult,
pubmed-meshheading:18059454-Aged,
pubmed-meshheading:18059454-Biological Markers,
pubmed-meshheading:18059454-Case-Control Studies,
pubmed-meshheading:18059454-Cross-Sectional Studies,
pubmed-meshheading:18059454-Early Diagnosis,
pubmed-meshheading:18059454-Female,
pubmed-meshheading:18059454-Humans,
pubmed-meshheading:18059454-Male,
pubmed-meshheading:18059454-Matrix Metalloproteinase 9,
pubmed-meshheading:18059454-Membrane Glycoproteins,
pubmed-meshheading:18059454-Middle Aged,
pubmed-meshheading:18059454-Prospective Studies,
pubmed-meshheading:18059454-Receptors, Virus
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pubmed:year |
2008
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pubmed:articleTitle |
Urinary biomarkers in the early diagnosis of acute kidney injury.
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pubmed:affiliation |
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. won.han@jefferson.edu
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, N.I.H., Extramural
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